Diagnosis, Physiological Mechanisms, Risk Factors, Treatment and ...
1 day ago · Obesity is a growing multifactorial problem globally over recent decades, characterized by the abnormal or excessive accumulation of adipose tissue that poses health risks (GONZÁLEZ-MUNIESA et al., 2017).According to the World Health Organization (ORGANIZAÇÃO MUNDIAL DE SAÚDE, 2024) in 2019, it is estimated that approximately 5 …
Obesity and metabolic syndrome in adults with a 22q11.2
4 days ago · Future studies that include data on parental obesity, other genetic risk factors (in addition to the 22q11.2 deletion), and social risk factors may further clarify the biological impact of the ...
ChREBP-mediated up-regulation of Them1 coordinates ... - Science
1 day ago · Brown and beige adipocytes use endogenous and exogenous fatty acids (FAs) and glucose as energy substrates (10, 11).Acute cold-induced stimulation of β 3-adrenergic receptors leads to oxidation of FA that are stored in cytoplasmic lipid droplets (LDs) and enhanced uptake of both FAs and glucose from the plasma (12, 13). β 3-adrenergic signaling also increases …
Arrowhead Pharmaceuticals Requests Regulatory Clearance to …
1 day ago · In large genetic datasets, reduced ACVR1C expression has been associated with healthier adipose distribution and reduced risk of obesity-related metabolic complications. ... An application for approval to initiate the clinical trial was submitted to the New Zealand Medicines and Medical Devices Safety Authority for review by the Standing ...
Setmelanotide licensed for treatment of severe obesity - Genetics …
3 days ago · We are excited to announce patients with three genetic conditions which cause obesity (POMC, PCSK1, LEPR) can now be treated with Setmelanotide, a Melanocortin-4 receptor (MC4R) agonist in the NHS following approval by NICE.
Obesity News - ScienceDaily
3 days ago · Oct. 25, 2024 — A new study has examined a large sample of privately insured patients with obesity and found that use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) as anti-obesity ...
Hepatic lipogenesis marked by GCKR‐modulated triglycerides …
5 days ago · The main results of this exploratory cross-sectional study are as follows: first, we replicated an association between the GCKR 446Leu variant and the circulating levels of FGF21 reported in adults in our clinic-based cohort of Italian children/adolescents with obesity, and second, we used this genetic association to shed new light in the cause ...
Atg5-deficient mesenchymal stem cells protect against non …
1 day ago · Non-alcoholic fatty liver disease (NAFLD) is a liver condition characterized by the abnormal accumulation of fat in the liver due to various factors, including genetic predisposition, obesity, high cholesterol, hypertension, diabetes, or other metabolic disorders [1, 2].NAFLD can progress to non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and potentially even …
Clinical Trial in MC4R Deficiency - Genetics of Obesity Study
4 days ago · In our recent paper published in Molecular Metabolism we include a comprehensive summary of all the known mutations in MC4R, the commonest genetic form of obesity. In this review of the field, we pulled together all the published papers, as well as unpublished data from our own team and from Karine Clement's team in Paris so that we could ...
Gut Microbiota–microRNA Interactions and Obesity ... - MDPI
5 days ago · Obesity is the fifth leading cause of death globally and its comorbidities put a high burden on societies and cause disability. In this review, we aim to summarize the interactions and crosstalk between gut microbiota (GM) and micro-RNA (miRNA) in obesity. We searched for the relevant literature through PubMed, Web of Science, Scopus, and Science Direct. The study …